Episode 5 links up to the same point where Episode 4 left off, with Lee's words to Campman the same as chosen in the former epiosde. Realizing Clementine is elsewhere in the city and not in the hospital morgue, he and the group that came with him look for a way out, as the herd of walkers seen in Episode 3 arrives in Savannah. Lee manages to open a nearby elevator door, but passes out after opening it from exertion and his bite.
Depending on who was brought with him, he can wake up among them or on his own, and ends up choosing whether to saw his arm off with a bonesaw in order to potentially save himself from the bite's infection or to at least buy him some time. Regardless, Lee and any others begin climbing the elevator shaft of the hospital, which is seen to be overrun by hordes of walkers on the inside and out. The group, or Lee, arrives on the roof and sees the streets crowded with thousands of walkers. However, using Molly's strategy from Episode 4, Lee manages to reach a bell tower next to the roof. Ringing it, he draws the hordes to the tower, thinning the streets and allowing the group to push on back to the manor.